Hybrids, Chimeras, Aberrant Nuptials:

IVIg conducts DC-platelet nuptials.

and -thromboglobulin) supports a packing or sorting defect rather than a defect in protein synthesis.5,7 By analogy, mice lacking chondroitin sulfate have -granules deficient in PF4, -thromboglobulin, and platelet-derived growth factor because of a granule-packing defect9 and patients lacking the vesicle-sorting protein VPS33B have -granule deficiency.10 Defects in protein packing, vesicle traf...

Chimeras of p14ARF and p16: Functional Hybrids with the Ability to Arrest Growth

The INK4A locus codes for two independent tumor suppressors, p14ARF and p16/CDKN2A, and is frequently mutated in many cancers. Here we report a novel deletion/substitution from CC to T in the shared exon 2 of p14ARF/p16 in a melanoma cell line. This mutation aligns the reading frames of p14ARF and p16 mid-transcript, producing one protein which is half p14ARF and half p16, chimera ARF (chARF), ...

Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples from The Cancer Genome Atlas (TCGA) reveals that transcription read-through beyond the terminati...

Mouse-chick neural chimeras.

Embryonic chimera production was used to study the developmental processes of the mouse nervous system. The difficulty of performing in situ transplantation experiments of neural primordium of mouse embryo was overcome by isotopic and isochronic grafting of mouse neural tube fragments into chick embryo. Mouse neural tube cells differentiated perfectly in ovo and neural crest cells associated wi...

Chimeras of nurture.